2的体液免疫应答性质和持久性研究
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2的体液免疫应答性质和持久性研究
2017-10-15

本期文章:《新英格兰医学杂志》:Online/在线发表

冰岛DeCODE Genetics-Amgen公司的Kari Stefansson团队对冰岛居民SARS-CoV-2的体液免疫应答进行了研究。2020年9月1日,该研究发表在《新英格兰医学杂志》上。

对SARS-CoV-2感染的体液免疫应答的性质和持久性,人们知之甚少。

研究组使用六种检测方法检测了来自冰岛的30576人血清样本的抗体,并确定若两项pan-Ig检测均为阳性,则为血清阳性。研究组从定量聚合酶链反应(qPCR)确诊的1237人身上采集了2102份样本,进行了为期4个月的检测。研究组还检测了4222名暴露于SARS-CoV-2的被隔离人员和23452名未知接触者的抗体。

从SARS-CoV-2感染中恢复的1797名患者中,接受检测的1215名患者中有1107名(91.1%)呈血清阳性。在qPCR确诊后的2个月内,通过两次pan-Ig分析测定的抗病毒抗体滴度增加,并在余下研究阶段保持稳定。

隔离人群中有2.3%呈血清阳性,未知接触者中有0.3%呈血清阳性。研究组估计,有0.9%的冰岛人感染了SARS-CoV-2,而感染致死率为0.3%。研究组还估计,在冰岛所有SARS-CoV-2感染者中,有56%已通过qPCR诊断出来,有14%在未经qPCR检测的隔离人群中(或已检测但呈阴性),30%在隔离区以外的人群中,尚未经qPCR检测。

研究结果表明,针对SARS-CoV-2的抗病毒抗体在诊断后4个月内未下降。研究组估计,SARS-CoV-2感染致死率为0.3%,且冰岛尚有44%的SARS-CoV-2感染者未接受qPCR检测。

附:英文原文

Title: Humoral Immune Response to SARS-CoV-2 in Iceland

Author: Daniel F. Gudbjartsson, Ph.D.,, Gudmundur L. Norddahl, Ph.D.,, Pall Melsted, Ph.D.,, Kristbjorg Gunnarsdottir, M.Sc.,, Hilma Holm, M.D.,, Elias Eythorsson, M.D., Ph.D.,, Asgeir O. Arnthorsson, M.Sc.,, Dadi Helgason, M.D., Ph.D.,, Kristbjorg Bjarnadottir, Ph.D.,, Ragnar F. Ingvarsson, M.D.,, Brynja Thorsteinsdottir, B.Sc.,, Steinunn Kristjansdottir, B.Sc.,, Kolbrun Birgisdottir, B.Sc.,, Anna M. Kristinsdottir, M.Sc.,, Martin I. Sigurdsson, M.D., Ph.D.,, Gudny A. Arnadottir, M.Sc.,, Erna V. Ivarsdottir, M.Sc.,, Margret Andresdottir, M.Sc.,, Frosti Jonsson, M.Sc.,, Arna B. Agustsdottir, M.Sc.,, Jonas Berglund, Ph.D.,, Berglind Eiriksdottir,, Run Fridriksdottir, M.Sc.,, Elisabet E. Gardarsdottir,, Magnus Gottfredsson, M.D., Ph.D.,, Olafia S. Gretarsdottir, B.Sc.,, Steinunn Gudmundsdottir, M.Sc.,, Kjartan R. Gudmundsson, B.Sc.,, Thora R. Gunnarsdottir, B.Sc.,, Arnaldur Gylfason, M.Sc.,, Agnar Helgason, Ph.D.,, Brynjar O. Jensson, M.Sc.,, Aslaug Jonasdottir, M.Sc.,, Hakon Jonsson, Ph.D.,, Thordur Kristjansson, M.D., Ph.D.,, Karl G. Kristinsson, M.D., Ph.D.,, Droplaug N. Magnusdottir, M.Sc.,, Olafur T. Magnusson, Ph.D.,, Lovisa B. Olafsdottir, M.D.,, Solvi Rognvaldsson, B.Sc.,, Louise le Roux, M.Sc.,, Gudrun Sigmundsdottir, M.D.,, Asgeir Sigurdsson, B.Sc.,, Gardar Sveinbjornsson, M.Sc.,, Kristin E. Sveinsdottir, B.Sc.,, Maney Sveinsdottir, B.Sc.,, Emil A. Thorarensen, B.Sc.,, Bjarni Thorbjornsson, B.Sc.,, Marianna Thordardottir, Ph.D.,, Jona Saemundsdottir, B.Sc.,, S. Hjortur Kristjansson, M.D.,, Kamilla S. Josefsdottir, M.D.,, Gisli Masson, Ph.D.,, Gudmundur Georgsson, B.Sc.,, Mar Kristjansson, M.D.,, Alma Moller, M.D., Ph.D.,, Runolfur Palsson, M.D.,, Thorolfur Gudnason, M.D.,, Unnur Thorsteinsdottir, Ph.D.,, Ingileif Jonsdottir, Ph.D.,, Patrick Sulem, M.D.,, and Kari Stefansson, M.D., Ph.D.

Issue&Volume: 2020-09-01

Abstract:

BACKGROUND

Little is known about the nature and durability of the humoral immune response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

METHODS

We measured antibodies in serum samples from 30,576 persons in Iceland, using six assays (including two pan-immunoglobulin [pan-Ig] assays), and we determined that the appropriate measure of seropositivity was a positive result with both pan-Ig assays. We tested 2102 samples collected from 1237 persons up to 4 months after diagnosis by a quantitative polymerase-chain-reaction (qPCR) assay. We measured antibodies in 4222 quarantined persons who had been exposed to SARS-CoV-2 and in 23,452 persons not known to have been exposed.

RESULTS

Of the 1797 persons who had recovered from SARS-CoV-2 infection, 1107 of the 1215 who were tested (91.1%) were seropositive; antiviral antibody titers assayed by two pan-Ig assays increased during 2 months after diagnosis by qPCR and remained on a plateau for the remainder of the study. Of quarantined persons, 2.3% were seropositive; of those with unknown exposure, 0.3% were positive. We estimate that 0.9% of Icelanders were infected with SARS-CoV-2 and that the infection was fatal in 0.3%. We also estimate that 56% of all SARS-CoV-2 infections in Iceland had been diagnosed with qPCR, 14% had occurred in quarantined persons who had not been tested with qPCR (or who had not received a positive result, if tested), and 30% had occurred in persons outside quarantine and not tested with qPCR.

CONCLUSIONS

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